Many chemical substances can harm you if they get on your skin, or if you accidentally breathe in their fumes, or swallow them. For this reason, you should always put on protective equipment when handling chemicals.
The types of protective gear used will depend on the type of chemical. You should always check the MSDS of the chemical to find out the types of hazard associated with the chemical and the safety equipment you should use when handling it.
Safety equipment can include latex gloves, aprons, dust masks, respirators, safety glasses and safety shields.